SYSTEMIC LUPUS ERYTHEMATOSUS AND THE COMPLEMENT SYSTEM
Authors:
Dušanka Martinović Kaliterna, Jadranka Morović Vergles, Mislav Radić
Summary
The complement system has important protective functions in both, the innate and the adoptive immune systems. Dysregulation of complement system can cause the tissue damage. The complement deficiency predispose to an infection, and also to a development of autoimmune diseases, especially systemic lupus erythematosus (SLE). The complement play an important role in the pathogenesis of SLE, and besides that the lower levels of complement´s compounds are well recognised as marker of SLE activity and also the activity of secondary APS.
Sažetak
Sustav komplementa ima važnu protektivnu ulogu kako u urođenoj tako i u stečenoj imunosti. Poremećaj regulacije sustava komplementa može prouzročiti upalno oštećenje tkiva. Manjak komplementa ima za posljedicu sklonost infekcijama, autoimunim bolestima, posebice sistemskom eritemskom lupusu (SLE). Pored značajne uloge komplementa u patogenezi SLE-a, sniženje razina komponenti komplementa je važan marker praćenja aktivnosti SLE-a i pridruženog antifosfolipidnog sindroma.
