STRONTIUM RANELATE’S (OSSEOR®) DUAL MODE OF ACTION: INCREASING BONE MASS AND DECREASING BONE RESORPTION
Authors:
Dušanka Martinović Kaliterna
Summary
Strontium ranelate has unique dual mode of action on bone remodeling through increased bone formation and decreased bone resorption. As a consequence, there is increased bone mass and bone strength, leading to reduced number of vertebral and nonvertebral fractures. Although strontium bone distribution is heterogeneous, higher concentrations of strontium are found in younger bones. Long term treatment with strontium ranelate does not lead to any change in bone mineral distribution, mineral composition or crystal stability, nor is strontium accumulated in bone.
Sažetak
Stroncij ranelat ima jedinstven dvostruki učinak na remodeliranje kosti kroz usporedno povećano stvaranje koštane mase i smanjenu resorpciju kost. Ukupni učinak odražava se u povećanju koštane mase i čvrstoći kosti rezultat čega je smanjen broj vertebralnih i nevertebralnih prijeloma. Premda ima heterogenu distribuciju, više koncentracije stroncija potvrđene su u mlađim kostima. Višegodišnja primjena stroncija nije pokazala značajnih promjena na razini minerala i kristala kao ni dugotrajno nakupljanje u skeletu
