KARDIOVASKULARNI POREMEĆAJI U REUMATOIDNOM ARTRITISU

Jadranka Morović-Vergles

Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease. Traditional cardiovascular risk factors (including male sex, family history for cardiovascular disease, age, dyslipidaemia, arterial hypertension, diabetes mellitus, smoking and obesity) do not adequately accunt for the extent of cardiovascular disease in RA. The pathogenesis of accelerated atherosclerosis in RA is not celar. Increasing evidence suggests a key role of inflammation in the onset and progression of atherosclerosis. Endothelial dysfunction represents the earliest manifestation of atherosclerosis. Hypertension prevalence in patients with RA is higher than that in the general population. It is attributable risk to the development of future cardiovascular events. Despite its serious complications, control of hypertension is far from adequate in the general population and even more so in rheumatoid arthritis patients.

Reumatoidni artritis (RA) je udružen s povećanim rizikom od kardiovaskularnih bolesti. Tradicionalni kardiovaskularni rizični čimbenici, uključujući muški spol, nasljeđe, dob, dislipidemiju, arterijsku hipertenziju, šećernu bolest, pretilost, pušenje, nisu dostatni za objašnjenje učestalosti kardiovaskularnih bolesti u RA. Patogeneza ubrzane ateroskleroze u RA nije jasna. Prevladava mišljenje da u nastanku i razvoju ateroskleroze primarnu ulogu ima upala. Endotelna disfunkcija najranije je očitovanje ateroskleroze. Hipertenzija je značajan rizični čimbenik za razvoj kardiovaskularnih bolesti, a prevalencija hipertenzije veća je u RA bolesnika nego u općoj populaciji. Usprkos visokoj prevalenciji hipertenzije i važnosti njenih komplikacije, kontrola hipertenzije daleko je od adekvatnog kako u općoj populaciji tako i u RA bolesnika.