EFFECTS OF DIET, LIFESTYLE, AND OTHER ENVIRONMENTAL FACTORS ON THE INCIDENCE OF RHEUMATOID ARTHRITIS

Broj: 2, 2017 Rubrika: Pregledni rad Autori: Nadica Laktašić-Žerjavić, Dragica Soldo-Jureša, Porin Perić, Simeon Grazio, Branimir Anić

Suočeni s dijagnozom kronične bolesti kao što je reumatoidni artritis (RA), bolesnici često razmišljaju o tome jesu li svojim dotadašnjim načinom života sami pridonijeli pojavi bolesti i što mogu učiniti da bi se izliječili. Pred javnozdravstvene sustave također se postavlja pitanje utvrđivanja okolišnih čimbenika rizika od razvoja RA te provođenja javnozdravstvenih mjera radi modificiranja tih rizičnih čimbenika, sniženja incidencije, a time i prevalencije RA kao kronične bolesti. Novije spoznaje o etiopatogenezi RA upućuju na moguće ekstrasinovijalno podrijetlo autoprotutijela
pod utjecajem okolišnih čimbenika. U ovome preglednom članku razmatrani su mogući okolišni čimbenici rizika od razvoja RA kao što su pušenje, kronične infekcije, disbioza mikrobioma pluća, gingive i crijeva, prehrana, status vitamina D, konzumiranje alkohola i kave, fizička aktivnost, debljina, kronični psihološki stres i socioekonomski status.

Faced with the diagnosis of a chronic disease such as rheumatoid arthritis (RA), patients oft en wonder whether they themselves have contributed to the development of the disease with their lifestyle and what lifestyle modifications are effective in order to cure the disease. On the other hand, it is important for the public health system to determine the environmental risk factors for the development of RA and to implement specific public health measures aimed at modifying those risk factors, in order to reduce the incidence and, consequently, the prevalence of RA as a chronic disease. New insights into the etiopathogenesis of RA suggest the possibility of an initial autoantibody disease origin from the exstrasynovial tissue, a pathogenic process which seems to be affected by environmental risk factors. In this review we discuss the possible environmental risk factors important for the development of RA, such as cigarette smoking, chronic infections, lung, gingival, and gut dysbiosis, nutrition, vitamin D status, alcohol and coff ee consumption, physical activity, obesity, chronic psychological stress, and socioeconomic status.

Broj posjeta: 5

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