RENOVASKULARNA HIPERTENZIJA UZROKOVANA TAKAYASU ARTERITISOM – PRIKAZ BOLESNICE

Krešimir Galešić, Jadranka Morović-Vergles, Marijana Živko, Ivana Račić, Domagoj Vergles, Zdravko Borković, Nada Čikeš

A 18-year old women with bilateral renal artery stenosis and renovascular hypertension as a part of Takayasu’s disease is presented. Takayasu’s disease is a chronic arteritis of unknown origin, primary affecting aorta and its branches. The disease is the most common in young women and is more common in the countries of eastern Asia in comparison with Western countries. Takayasu’s disease can be severe and lifetreating disease. Mortality and morbidity depend on both the direct effect of the vascular lesions and the complications od disease. The mainstay of Takayasu’s disease is based on the use of glucocorticoids alone or in association with cytotoxic drugs (cyclofosfamid, azatioprin, metotrexate). In the majority of cases, the partial control of disease is obtained.

U radu je prikazana 18-godišnja bolesnica s obostranom stenozom bubrežnih arterija i renovaskularnom hipertenzijom u sklopu Takayasu arteritisa. Takayasu arteritis kronični je arteritis nepoznate etiologije koji zahvaća aortu i njene ogranke. Bolest se javlja u mladih žena, češće u zemljama istočne Azije nego u zemljama Zapada. Takayasu arteritis je često teška i smrtonosna bolest, a mortalitet i morbiditet ovisi o proširenosti vaskularnih lezija sa sljedstvenim ishemijama. U liječenju se primjenjuju glukokortikoidi sami ili u kombinaciji sa citostaticima (ciklofosfamid, azatioprin, metotreksat). U većine bolesnika pravovremenom primjenom tih lijekova postiže se djelomična remisija.