HORMONAL THERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors:
Dušanka Martinović Kaliterna, Danijela Marasović Krstulović, Mislav Radić
Summary
Estrogens favor the development and/or exacerbation of systemic lupus erythematosus (SLE). Numerous reports have described the association between estrogens exposure (oral contraceptives and menopause hormonal therapy) and development or exacerbation of SLE. Some new studies showed benefit from oral contraceptives and other hormonal therapies without a change in lupus activity but with increased risk of thrombosis. Hormonal therapy in SLE patients should be individual according to clinical presentation and progression of the disease.
Sažetak
Estrogeni neosporno imaju upliv na javljanje i tijek lupusne bolesti. Prema dosadašnjim spoznajama primjena estrogena u kontraceptivima ili hormonalnoj nadomjesnoj terapiji poticala je pogoršanje ili početak bolesti. Noviji radovi nameću značajno mekši stav prema estrogenima u SLE-u budući da su pogoršanja koja oni mogu izazvati većinom blaga do umjerena, ali je ponovno potvrđen povećan rizik tromboembolija. Klinička odluka valja biti pojedinačna zavisna o naravi i tijeku bolesti.
