NONSTEROIDAL ANTIRHEUMATICS AND THE KIDNEY
Authors:
Krešimir Galešić, Jadranka Morović-Vergles, Bojan Jelaković
Summary
The renal side effects of nonsteroidal anti-inflammatory drugs are very often and could be seen in 5% of patients who are treated with this drugs. These side effects could be separated in 5 clinical syndromes: 1. acute renal failure, 2. acute interstitial nephritis with nephrotic syndrome, 3. electrolyte and fluid disorders, 4. hypertension and 5. analgesic nephropathy. There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).
Sažetak
Bubrežne nuspojave nesteroidnih antireumatika javljaju se u oko 5% bolesnika koji uzimaju te lijekove. Klinička očitovanja nefrotoksičnih učinaka tih lijekova mogu se svrstati u pet sindroma: 1. akutna bubrežna insuficijencija, 2. akutni intersticijski nefritis s nefrotskim sindromom, 3. poremećaji elektrolita (natrija i kalija) i tjelesnih tekućina, 4. hipertenzija i 5. analgetska nefropatija. Brojna istraživanja pokazala su da selektivni COX-2 inhibitori (rofekoksib i celekoksib) mogu izazvati slične štetne učinke na bubrezima kao klasični nesteroidni antireumatici (inhibitori COX-1 i COX-2).
