THE CLINICAL PICTURE OF RHEUMATOID ARTHRITIS - THE COMPLEX OF THREE INDEPENDENT MECHANISMS

Authors:

Hans Georg Fassbender, Carola Meyer-Scholten, Kati Zorn

Summary

The assumption of infl amation as the only cause of the complex clinical picture of rheumatoid atrhritis does not correspond to facts. We have found and proven the existence of three seemingly unconnected mechanisms, and only their combination can account for the general clinical picture of rheumatoid arthritis. They are: 1. immunologic synovitis, responsible for pain, swelling and stiffnes; 2. oncological process (“tumorlike proliferation”), responsible for the destruction of joints; 3. Primary necrotizing process, responsible for the (sometimes lethal) destructions in the heart and blood vessels.

Sažetak
Shvaćanje o upalnoj bolesti kao jedino odgovornoj za složenu kliničku sliku reumatoidnog artritisa (a o čemu svjedoči i sám naziv bolesti) zapravo ne odgovara činjenicama. Naprotiv, našli smo i potvrdili postojanje triju, naoko međusobno neovisnih mehanizama, i tek njihova kombinacija može objasniti ukupnu kliničku sliku reumatoidnog artritisa. To su: 1. imunološki sinovitis, odgovoran za bol, otekline i zakočenost; 2. onkološki proces (“tumor-like proliferation”), odgovoran za razaranje zglobova; 3. primarno nekrotizirajući proces, odgovoran za (kadšto smrtonosna) razaranja u srcu i krvnim žilama.

Vol.: 56

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